hs-CRP/HDL ratio: normal range and what your result means

What is HS-CRP / HDL Ratio?

The HS-CRP / HDL ratio is the relationship between high-sensitivity C-reactive protein (HS-CRP), an indicator of inflammation, and HDL, the “good” cholesterol that helps remove fat from the bloodstream. This ratio provides a snapshot of inflammation levels relative to cholesterol health.

Why does it matter for long-term health and wellbeing?

The HS-CRP / HDL ratio is a useful indicator of inflammation and heart health, with a lower ratio reflecting better balance between inflammation and cardiovascular health. Tracking this ratio helps optimise overall wellness, energy, and metabolism over time.

What's an optimal level of HS-CRP / HDL Ratio?

Optimal Range:

• HS-CRP: Less than 1 mg/L for low inflammation
• HDL: Above 1.0 mmol/L (an optimal ratio would show low CRP levels and high HDL, suggesting a healthier balance).

What influences HS-CRP / HDL levels?

Factors such as diet, physical activity, weight, and stress levels can impact these biomarkers. Regular exercise, a healthy diet, and stress management can support optimal levels.

What does it mean if HS-CRP / HDL is outside the optimal range?

A higher HS-CRP and a lower HDL may signal increased inflammation or suboptimal cardiovascular health, indicating areas where lifestyle improvements could be beneficial.

How can I support healthy HS-CRP / HDL levels?

To maintain healthy levels, focus on a balanced diet rich in antioxidants, omega-3 fatty acids, and healthy fats, regular physical activity, weight management, and stress reduction techniques like mindfulness or relaxation exercises.

References

1. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice. Circulation. 2003. doi:10.1161/01.CIR.0000052939.59093.45. PMID: 12551878.
2. Pathology Tests Explained. HDL cholesterol. https://ptex.au/ptests.php?q=HDL+cholesterol
3. Gao Y, Wang M, Wang R, et al. The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study. Lipids in Health and Disease. 2024;23:66. doi:10.1186/s12944-024-02055-7.