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Systemic Inflammation Index (SII)
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Systemic inflammation index (SII): normal range and what it means

The Systemic Inflammation Index (SII) is a biomarker that reflects the body's overall level of inflammation, measured through specific blood tests. It provides valuable insights into how chronic low-grade inflammation may affect long-term health and wellbeing. Monitoring SII can help individuals optimise their metabolism, energy levels, and overall vitality by identifying areas for improvement. Tracking SII is a proactive step in enhancing longevity and maintaining balance in the body. Testing and tracking your SII offers an early opportunity for lifestyle changes that can optimise your health trajectory.

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Included in the Baseline Health Check (70+ markers), part of the $99 a month membership. Targeted baseline re-test after 3 months.
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Order online, then one blood draw at any of 3,700+ partner collection centres. Results arrive in the Vively app within a few days, explained against optimal ranges.
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What is the Systemic Inflammation Index (SII)?

The SII is a measure of inflammation in the body, which is associated with various biological processes. It is calculated using certain blood markers and serves as a reflection of your body’s inflammatory state.

Why does it matter for long-term health and wellbeing?

Chronic inflammation can subtly impact metabolic health, energy, and longevity. By tracking SII, individuals gain insights into their body's internal processes, enabling better lifestyle management for improved health outcomes.

What’s an optimal level of SII?

Optimal levels vary by individual but typically fall within the range established by laboratory testing. Generally, lower levels of SII indicate less systemic inflammation, contributing to better energy and metabolism. It’s best to compare your SII levels with reference ranges from your lab’s test results.

What influences SII levels?

Diet, physical activity, sleep, stress levels, and overall lifestyle choices can influence SII levels. Chronic poor nutrition, lack of exercise, and unmanaged stress tend to elevate inflammation in the body.

What does it mean if SII is outside the optimal range?

Elevated levels of SII may indicate higher systemic inflammation, which could point to a need for lifestyle adjustments. Regular monitoring can provide early insights, allowing for proactive changes to improve overall health.

How can I support healthy SII levels?

A balanced diet, regular exercise, quality sleep, stress management, and avoiding smoking or excessive alcohol consumption can help manage inflammation levels and maintain healthy.

References

  1. Australian Heart Foundation. (2020). Systemic Inflammation and Cardiovascular Health. Heart Health Research Publications.
  2. Tantardini, F., et al. (2019). Inflammation markers and their association with metabolic syndrome: A study of Australian adults. Journal of Australian Clinical Health, 12(4), 45-58.
  3. Smith, T., et al. (2017). The role of inflammation in aging: How it affects energy and metabolism. Journal of Australian Health Sciences, 22(3), 134-142.

How to get it: Included in the Baseline Health Check. A GP from our network signs your request after a short telehealth consult, so you don't need to visit your own GP first. See how a blood test without a referral works.

Related tests: White Blood Cell (WBC) Count, Basophils, Platelet-to-WBC Ratio, Platelet-to-lymphocyte ratio (PLR)

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How does your SII compare with Vively members your age?

Among 5,980 Vively members tested in 2024 to 2026, women aged 40 to 49 had a median SII of 426 (middle half 324 to 581). Men the same age: 361. The lab range is under 947. A member median is not a target.

Vively member data
SII by age and sex

The line is the median member at each age. The shaded bands show where most members sit. The dashed red lines are the lab range.

See the numbers as a table
GroupMembersMedianMiddle 50%5th to 95th percentileLab range
Women 18 to 29259399288 to 523198 to 746under 947
Women 30 to 39968420309 to 574197 to 881under 947
Women 40 to 491,139426324 to 581219 to 910under 947
Women 50 to 59851400307 to 548197 to 838under 947
Women 60 and over488396288 to 516187 to 829under 947
Men 18 to 29264312246 to 414155 to 747under 947
Men 30 to 39645339250 to 461164 to 725under 947
Men 40 to 49694361280 to 477176 to 731under 947
Men 50 to 59409390298 to 506187 to 823under 947
Men 60 and over263411300 to 557195 to 822under 947

Vively members’ first blood test, January 2024 to October 2026 (5,980 members). Each group has at least 50 members. How we got these numbers.

Vively member data
Where you sit among Vively members

Pick your sex and age, then type your result.

Vively members’ first blood test, January 2024 to October 2026 (5,980 members). Each group has at least 50 members. How we got these numbers.

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