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Blood Testing

The Systemic Inflammation Index (SII)

The Systemic Inflammation Index (SII) is a biomarker that reflects the body's overall level of inflammation, measured through specific blood tests. It provides valuable insights into how chronic low-grade inflammation may affect long-term health and wellbeing. Monitoring SII can help individuals optimise their metabolism, energy levels, and overall vitality by identifying areas for improvement. Tracking SII is a proactive step in enhancing longevity and maintaining balance in the body. Testing and tracking your SII offers an early opportunity for lifestyle changes that can optimise your health trajectory.

The Systemic Inflammation Index (SII) is available in Full Body Health Check. Book your blood test now!
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What is the Systemic Inflammation Index (SII)?

The SII is a measure of inflammation in the body, which is associated with various biological processes. It is calculated using certain blood markers and serves as a reflection of your body’s inflammatory state.

Why does it matter for long-term health and wellbeing?

Chronic inflammation can subtly impact metabolic health, energy, and longevity. By tracking SII, individuals gain insights into their body's internal processes, enabling better lifestyle management for improved health outcomes.

What’s an optimal level of SII?

Optimal levels vary by individual but typically fall within the range established by laboratory testing. Generally, lower levels of SII indicate less systemic inflammation, contributing to better energy and metabolism. It’s best to compare your SII levels with reference ranges from your lab’s test results.

What influences SII levels?

Diet, physical activity, sleep, stress levels, and overall lifestyle choices can influence SII levels. Chronic poor nutrition, lack of exercise, and unmanaged stress tend to elevate inflammation in the body.

What does it mean if SII is outside the optimal range?

Elevated levels of SII may indicate higher systemic inflammation, which could point to a need for lifestyle adjustments. Regular monitoring can provide early insights, allowing for proactive changes to improve overall health.

How can I support healthy SII levels?

A balanced diet, regular exercise, quality sleep, stress management, and avoiding smoking or excessive alcohol consumption can help manage inflammation levels and maintain healthy.

References

  1. Australian Heart Foundation. (2020). Systemic Inflammation and Cardiovascular Health. Heart Health Research Publications.
  2. Tantardini, F., et al. (2019). Inflammation markers and their association with metabolic syndrome: A study of Australian adults. Journal of Australian Clinical Health, 12(4), 45-58.
  3. Smith, T., et al. (2017). The role of inflammation in aging: How it affects energy and metabolism. Journal of Australian Health Sciences, 22(3), 134-142.

What we measure

 70+ biomarkers analysed, each one tells you something specific about how your body is functioning right now, not just whether you're "sick" or "not sick"

Understand markers linked to healthy aging

A reflection of how your body is aging at the cellular level, linked to age risks and longevity.

  • Biological Age
  • Speed of Aging

Understand how your body regulates energy

Review glucose, insulin and lipid markers associated with metabolic balance.

  • Fasting Glucose
  • Fasting Insulin
  • Haemoglobin A1c (HbA1c) IFCC mmol/m
  • Haemoglobin A1c (HbA1c) NGSP/DCCT %
  • HOMA-IR
  • Uric Acid/HDL-C (UHR)
  • TyG index
  • Sodium/Potassium Ratio
  • hs-CRP / HDL Ratio

See how your blood supports oxygen and energy

Key blood indicators like hemoglobin, inflammation, and oxygen transport for overall health.

  • Mean Cell Volume (MCV)
  • Red Blood Cell (RBC) Count
  • Haemoglobin
  • Haematocrit
  • Red cell distribution width (RDW)
  • Mean Cell Haemoglobin (MCH)
  • Mean Cell Haemoglobin Concentration (MCHC)
  • Platelet count

Review advanced cardiovascular risk markers

Analyse lipid balance and related markers linked to long-term heart and vascular wellbeing.

  • Total Cholesterol
  • LDL Cholesterol
  • HDL Cholesterol
  • Non-HDL Cholesterol
  • Cholesterol Ratio
  • Triglycerides
  • Cholesterol/HDL Ratio
  • Total Cholesterol/HDL Ratio
  • LDL/HDL Ratio
  • Triglyceride/HDL Cholesterol (Molar Ratio)
  • Non-HDL Cholesterol/Total Cholesterol (Mass Ratio)
  • Atherogenic Index of Plasma (AIP)

See how your immune system is functioning

Review white blood cell markers that reflect immune activity and response.

  • White Blood Cell (WBC) Count
  • Neutrophils
  • Lymphocytes
  • Eosinophils
  • Basophils
  • Neutrophil-to-Lymphocyte Ratio
  • Neutrophil-to-HDL Cholesterol Ratio (NHR)
  • Platelet/Lymphocyte Ratio
  • Monocytes

Identify markers linked to systemic inflammation

Assess signals associated with inflammatory balance and overall physiological stress.

  • High-Sensitivity C-Reactive Protein (hs-CRP)
  • CRP/Albumin Ratio (CAR)
  • Systemic Inflammation Index (SII)

Monitor markers related to kidney function

Review indicators that reflect how efficiently your kidneys filter and regulate fluids.

  • Chloride
  • Bicarbonate
  • Sodium
  • Potassium
  • Urea
  • Creatinine
  • BUN/Creatinine Ratio
  • Estimated Glomerular Filtration Rate (eGFR)
  • Anion Gap

Assess markers connected to liver health

Understand enzymes and related markers linked to metabolic processing and detoxification pathways.

  • Alkaline Phosphatase
  • Bilirubin
  • Aspartate aminotransferase (AST)
  • Gamma-glutamyl Transferase (GGT)
  • Alanine Aminotransferase (ALT)
  • Globulin
  • Total Protein
  • NAFLD FIB-4
  • Albumin/Globulin Ratio
  • Albumin

Check your thyroid function

Helps identify thyroid issues linked to energy, mood and weight.

  • Thyroid Stimulating Hormone (TSH)

Check key nutrient levels that support daily function

Assess essential vitamins and minerals linked to energy production, recovery and overall wellbeing.

  • Iron
  • Phosphate
  • Magnesium
  • Transferrin
  • Ferritin
  • Transferrin saturation
  • TIBC
  • Vitamin D
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Markers analysed
70+ markers
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If needed, we'll recommend further testing to investigate potential issues based on your results

01

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One simple test to understand where your health stands. Visit one of 4,000 collection centres across Australia at your earliest convenience and take one easy blood draw.
02

Review your results

Meet with a registered health professional to identify what looks fine, what’s worth watching, and what (if anything) needs attention. If nothing needs changing, we’ll tell you that too.
03

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After your baseline, Vively continues as ongoing guidance — helping you stay on track, adjust when something changes, and re-test every 3 months to see progress over time.
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Practitioner support

  • Test reviews and guidance from a registered nurse trained in optimal health
  • Dietitian support for nutrition and lifestyle changes
  • Plan updates whenever your results change

Ongoing monitoring

  • A full Baseline available every 3 months
  • See every marker trend over time
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