What is the AST/ALT ratio?
The AST/ALT ratio is the proportion between two liver enzymes—AST and ALT—measured in blood tests. It reflects how well your body processes nutrients and supports cellular energy function.
Why does it matter for long-term health and wellbeing?
A balanced AST/ALT ratio reflects healthy metabolic activity and efficient recovery from daily physical or dietary stress. It helps you understand how lifestyle factors may be influencing your liver’s ability to support energy and performance.
What’s an optimal level of AST/ALT ratio?
- Typical Australian reference range: approximately 0.7–1.3
- Optimal range for wellbeing: around <1.0 (These values can vary slightly depending on the lab and sex.)
What influences AST/ALT ratio levels?
Levels can be influenced by factors such as alcohol intake, body composition, hydration, exercise intensity, medications, and overall diet quality. Even short-term changes like fasting or strenuous workouts can affect readings.
What does it mean if AST/ALT ratio is outside the optimal range?
A result trending higher or lower may reflect shifts in enzyme activity related to energy metabolism, protein balance, or recovery. It’s useful as an early lifestyle insight to guide improvements in rest, nutrition, and physical activity.
How can I support healthy AST/ALT ratio levels?
- Maintain balanced nutrition with adequate protein and antioxidants
- Support hydration and limit excess alcohol
- Stay active but allow time for recovery
- Prioritise sleep and stress management
- Re-test regularly to track improvements over time
This information is provided for general health and wellness purposes only and does not replace medical advice.
References
- Royal College of Pathologists of Australasia. Aspartate aminotransferase (AST) – RCPA Manual (Pathology Tests). Available online.
- Royal College of Pathologists of Australasia. Alanine aminotransferase – RCPA Manual (Pathology Tests).
- Prati D, Taioli E, Zanella A, et al. Updated Definitions of Healthy Ranges for Serum Alanine Aminotransferase Levels. Annals of Internal Medicine. 2002;137(1):1-10.
- Ndrepepa G, et al. De Ritis ratio and cardiovascular disease: evidence and clinical perspectives. Journal of Laboratory Precision Medicine. 2023.
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