What is caeruloplasmin?

Caeruloplasmin is a major copper-transport protein that moves copper around the body and helps regulate how this mineral is stored and used. It forms part of the body’s broader antioxidant and metabolic systems and provides a clearer picture of long-term copper status than spot measures alone.

Why does it matter for long-term health and wellbeing?

Copper plays a role in energy production, connective tissue integrity, and overall metabolic efficiency. Caeruloplasmin helps indicate whether your body is maintaining a balanced supply of copper to support these functions. Understanding your level allows you to optimise lifestyle choices that contribute to sustained wellbeing and performance.

What’s an optimal level of caeruloplasmin?

• Laboratory reference range: 0.24–0.60 g/L
• Optimal range for proactive health: Typically towards the mid-range (around 0.30–0.50 g/L), though individual targets can vary.

These ranges offer guidance on where copper-transport activity generally supports balanced physiological function.

What influences caeruloplasmin levels?

Caeruloplasmin can be shaped by copper intake, oestrogen levels, liver synthesis capacity, pregnancy, alcohol intake, inflammation, hydration status, and certain medications. Lifestyle patterns such as diet quality, stress load, and overall metabolic health may also play a role.

What does it mean if caeruloplasmin is outside the optimal range?

Levels below the optimal range may indicate that your system has limited available copper or reduced ability to transport it efficiently. Higher levels may reflect increased copper availability, hormonal influences, or altered protein production. These patterns offer a prompt to review nutrition, daily habits, and overall health behaviours to support balance.

How can I support healthy caeruloplasmin levels?

Focus on nutrient-dense foods containing copper (such as nuts, seeds, legumes, grains, and shellfish), maintain stable energy and stress patterns, and support overall liver wellbeing through balanced nutrition, movement, and sleep. Regular testing helps you see how small lifestyle adjustments influence your copper status over time.

This information is provided for general health and wellness purposes only and does not replace medical advice.

References

1. National Health and Medical Research Council. (2013). Australian Dietary Guidelines. NHMRC.
2. Australian Government Department of Health and Aged Care & National Health and Medical Research Council. (2006). Nutrient Reference Values for Australia and New Zealand. Commonwealth of Australia.
3. Gibson, R. S. (2005). Principles of Nutritional Assessment (2nd ed.). Oxford University Press.
4. Linder, M. C. (2016). Ceruloplasmin and other copper binding components of blood plasma and their functions. Biometals, 29(3), 283–308.