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Cortisol/DHEA-S Ratio Blood Test: What Low, High and Optimal Cortisol/DHEA-S Ratio Levels Mean.

The Cortisol/DHEA-S Ratio is a key indicator of your body's stress response and overall balance. Cortisol, a hormone produced in response to stress, and DHEA-S, a hormone that supports energy production and regeneration, are both vital for energy, metabolism, and longevity. By monitoring this ratio, you can gain valuable insights into how your body is coping with stress and whether you're optimising your performance and wellbeing. Testing this biomarker gives you a clearer understanding of your hormonal balance, empowering you to make proactive lifestyle changes for long-term health.

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Dr Michelle Woolhouse
July 1, 2026
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What is the Cortisol/DHEA-S Ratio?

The Cortisol/DHEA-S ratio measures the balance between two hormones: cortisol, which helps manage stress, and DHEA-S, which is involved in energy and recovery. Tracking this ratio provides insights into how your body is adapting to stress and managing long-term energy levels.

Why does it matter for long-term health and wellbeing?

This ratio offers a clear view of how well your body manages stress and maintains energy. High cortisol levels, particularly when combined with low DHEA-S, can indicate that your body is not recovering effectively, which may impact your overall wellbeing. By keeping the ratio balanced, you support healthy energy metabolism and stress resilience.

What’s an optimal level of Cortisol/DHEA-S?

The optimal range for the Cortisol/DHEA-S ratio can vary, but generally, a balanced ratio suggests better energy regulation and recovery. It's important to track your personal baseline and adjust as needed for your health goals. The reference ranges from your lab will offer a guideline for interpreting your results.

What influences Cortisol/DHEA-S levels?

Factors like stress, sleep quality, diet, exercise, and lifestyle habits can all impact your cortisol and DHEA-S levels. Chronic stress, poor sleep, and inadequate nutrition can disrupt your hormonal balance, leading to imbalances in this ratio.

What does it mean if the Cortisol/DHEA-S ratio is outside the optimal range?

If the ratio is imbalanced, it may indicate that your body is experiencing heightened stress or insufficient recovery. This could lead to fatigue, difficulty managing stress, or lower energy levels over time. Regular monitoring can help you identify when adjustments to your lifestyle or habits are needed.

How can I support healthy Cortisol/DHEA-S levels?

To maintain a healthy ratio, focus on managing stress through mindfulness, exercise, and proper sleep. A balanced diet rich in antioxidants, vitamins, and minerals supports overall hormone production. Regular physical activity and a consistent sleep schedule can also help improve balance.

References

  1. Australian Institute of Health and Welfare. (2020). Hormonal health and wellbeing in Australia: Trends and statistics. AIHW.
  2. Zimmet, P.Z., Alberti, K.G.M., & Shaw, J. (2001). Global and societal implications of the diabetes epidemic. Nature, 414(6865), 782-787.
  3. Pereira, M. A., & Figueiredo, L. R. (2016). Impact of stress on health in adults: A review. Australian Journal of Psychology, 68(3), 179-188.

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