Home / Blog /

The role of exercise in skeletal muscle energy metabolism

Woman exercising in her living room
Glucose management

The role of exercise in skeletal muscle energy metabolism

November 8, 2022

Discover how high-intensity and aerobic exercise impact metabolism, muscle energy and glucose control. Continue reading to find out how different types of exercise, according to the most recent evidence-based research, can help stimulate the mitochondrial membrane, lower blood sugar levels and manage diabetes.

Key Takeaways:

  • High-intensity and aerobic exercises play a vital role in skeletal muscle energy metabolism and oxidative metabolism.
  • Regular exercise can lead to enhanced glucose control and decreased blood sugar levels.
  • Exercise is an effective tool in the management and prevention of diabetes.

As we learn more about skeletal muscle energy metabolism during exercise and oxidative metabolism, we'll see how important exercise, particularly high-intensity and aerobic exercise, is for maintaining metabolic health and managing glucose levels.

Exercise is necessary for maintaining metabolic health. Regular physical activity improves body composition, insulin sensitivity and resting metabolic rate through increases in calories burnt at rest. These changes improve energy use, control glucose and can prevent or manage metabolic disorders like diabetes and metabolic syndrome.

Exercise has many effects on metabolic health. Engaging in physical activity helps our muscles use energy better, particularly high-intensity exercise that breaks down glycogen quickly. Aerobic exercise, on the other hand, helps burn fat.

Regular exercise helps maintain a healthy balance of energy in the body. This reduces the risk of having too much fat. It also reduces the risk of related health problems.

Exercising regularly also improves oxidative metabolism, the process through which our bodies turn fats and carbs into useful energy by using oxygen. This leads to improved endurance, better performance, and, more importantly, efficient glucose control, a crucial element in metabolic health.

Exercise is crucial for maintaining excellent metabolic health and should not be overlooked. It is a powerful, natural instrument for enhancing general health and wellbeing.

Skeletal muscle substrates during exercise

Adenosine triphosphate, or ATP, is the source of energy needed and stored in all cells to allow the body to function optimally. Our muscles have an intricate system for ATP synthesis that uses numerous substrates to produce energy. The substrates used depend on the type of exercise you perform.

High-intensity exercise, such as sprinting or weightlifting, requires rapid energy production, which is mostly supplied by glycogen, a type of stored glucose found in your muscles and liver.

The rapid breakdown of glycogen (glycogenolysis) provides a quick source of glucose for anaerobic metabolism, leading to the formation of lactate. It's crucial to note that while glycogen is a prime energy source for high-intensity exercise, its stores are limited. Therefore, regular consumption of carbohydrates is essential to replenish glycogen stores and sustain high-intensity exercise performance.

During extended, moderate-intensity aerobic exercise, such as jogging or cycling, your muscles predominantly rely on fat oxidation for sustained energy production.

Lipolysis (fat breakdown process) releases fatty acids, which are passed on to muscle cells and used in the mitochondria to make energy. This process, known as beta-oxidation, occurs within the realm of oxidative metabolism, where oxygen is readily available.

While fat is a rich energy source, its breakdown is slower than glycogenolysis. Therefore, the body prefers to utilise fat during lower-intensity, longer-duration activities when the demand for immediate energy is lower.

The type of exercise we engage in influences how our muscles utilise different energy substrates. Glycogen is quickly used for energy quickly during high-intensity activity, while fat oxidation becomes the primary energy source during moderate-intensity aerobic exercise.

Understanding how our bodies use different substrates during exercise provides valuable insight into our metabolic health.

The power of high-intensity exercise in skeletal muscle energy metabolism

High-intensity exercise is a vigorous form of physical activity that pushes your body to its limits. It improves skeletal muscle energy metabolism, a vital process that allows our muscles to efficiently make and use energy.

During high-intensity exercise, our bodies primarily rely on anaerobic glycolysis for energy production. However, this doesn't negate the significance of oxidative metabolism. In fact, evidence indicates that repeated high-intensity exercise sessions can enhance oxidative capacity, essentially training our muscles to better utilise oxygen for energy production, a key factor in endurance and long-term performance.

High-intensity exercise also prompts significant glucose uptake into the skeletal muscles, effectively answering the question, "Will exercise lower blood sugar?" Yes, it certainly can! This mechanism is crucial to maintaining normal blood sugar levels, especially for those with diabetes or pre-diabetes.

Here are some examples of high-intensity exercises that could be incorporated into a routine to support skeletal muscle energy metabolism:

  • High-intensity interval training (HIIT) involves alternating short periods of intense anaerobic exercise with less-intense recovery periods.
  • Sprinting could be done on flat ground or up a hill, either on foot or on a bike.
  • Circuit exercise training consists of a series of exercises performed one after the other with minimal rest in between.
  • Plyometrics are explosive, high-impact exercises such as jump squats or burpees.
  • Heavy weight lifting involves muscle contraction by lifting heavy weights for fewer repetitions, which engages the anaerobic energy system.
  • Intense swimming drills or sprinting laps in a pool doing high-intensity water aerobics can be excellent for boosting skeletal muscle energy metabolism.

Aerobic exercise and oxidative metabolism

While high-intensity exercises are powerful, aerobic exercises should not be overlooked. Engaging in regular, moderate-intensity aerobic exercise like swimming, walking or cycling can significantly stimulate oxidative metabolism.

Aerobic exercise enhances the skeletal muscle's oxidative capacity—the ability to use oxygen to generate energy from carbohydrates and fats. In other words, the more you exercise aerobically, the better your muscles become at using oxygen to convert food into usable energy. This, in turn, leads to improved muscle endurance, metabolic health and efficiency.

Moreover, aerobic exercise increases the capacity of skeletal muscles to absorb glucose from the bloodstream, contributing to the lowering of blood sugar levels. Regular aerobic exercise is therefore a powerful tool in the management and prevention of diabetes.

Here are some examples of aerobic exercises that can be integrated into a routine to support oxidative metabolism:

  • Walking: A brisk walk is a simple, accessible form of aerobic exercise.
  • Running or jogging: This can be done at a steady, moderate pace to maintain a longer duration.
  • Cycling: Whether it's done outdoors or on a stationary bike, cycling is an excellent aerobic activity.
  • Swimming: This is a full-body exercise that can significantly stimulate oxidative metabolism.
  • Dancing: Engaging in dance classes or even freestyle dancing at home can contribute to aerobic fitness.
  • Hiking: This combines the benefits of walking with additional effort due to changes in elevation.
  • Rowing: If you have access to a rowing machine, it provides an effective full-body aerobic workout.
  • Aerobic classes: Fitness classes such as step aerobics, Zumba or spin classes can offer a fun and varied aerobic workout.

The link between exercise and diabetes

Both glycogen and fat metabolism play roles in blood sugar control, which is vital in preventing diabetes. The breakdown of glycogen into glucose directly impacts blood glucose levels, highlighting its importance in glucose management. Similarly, when the body uses fat as a primary fuel source during aerobic exercise, it reduces its reliance on glycogen, thereby helping to maintain blood glucose levels over longer periods.

Extensive research shows the strong correlation between regular exercise and improved glycaemic control, making physical activity a cornerstone in the prevention and management of diabetes. Exercise increases insulin sensitivity, enabling your body to use insulin more efficiently, lowering blood sugar and reducing the risk of developing type 2 diabetes.

One of the key ways exercise supports metabolic health and improves insulin sensitivity is by enhancing the functionality of the mitochondria, often referred to as the powerhouse of the cell. Mitochondria play a vital role in energy production through a process called oxidative phosphorylation.

Oxidative phosphorylation is one of the metabolic pathways that uses energy released by the oxidation of nutrients to produce adenosine triphosphate (ATP). This process occurs within the mitochondrial membrane, and its efficiency is integral to overall metabolic health.

When we engage in exercise, particularly aerobic activity, we're essentially training our mitochondria to be more efficient at oxidative phosphorylation. Regular physical stress from exercise encourages the formation of more mitochondria (a process known as mitochondrial biogenesis) and improves the functionality of existing ones. As a result, your muscles become better at using glucose, which improves insulin sensitivity and helps regulate blood sugar levels.

The effectiveness of exercise in managing diabetes is dependent on regularity, intensity and duration. Both high-intensity and aerobic exercises have unique benefits, and incorporating a mix of both can yield optimal results.

Regular exercise also promotes fat loss and muscle gain, further aiding in blood sugar control and reducing the risk of diabetes-related complications. The role of exercise in managing diabetes is multifaceted and highlights the integral relationship between physical activity and metabolic health.

Understanding the effects of exercise on our metabolic processes and its impact on our health is made easier with tools like Vively, an empowering metabolic health app that helps us make informed decisions and enhance our overall metabolic health through evidence-based strategies.

By tracking your response to different types of exercises and providing personalised guidance based on your data, Vively can help you tailor your workouts to optimise substrate usage and blood glucose control. In this way, Vively is not just a metabolic health app but a partner in your journey towards a healthier, more informed life.

Get irrefutable data about your diet and lifestyle by using your own glucose data with Vively’s CGM Program. We’re currently offering a 20% discount for our annual plan. Sign up here.

Meet our team.

Subscribe to our newsletter & join a community of 20,000+ Aussies

Get access to limited content drops, free invites to expert fireside chats, and exclusive offers.

The role of exercise in skeletal muscle energy metabolism
November 8, 2022

The role of exercise in skeletal muscle energy metabolism

Discover how high-intensity and aerobic exercise impact metabolism, muscle energy and glucose control. Continue reading to find out how different types of exercise, according to the most recent evidence-based research, can help stimulate the mitochondrial membrane, lower blood sugar levels and manage diabetes.

Key Takeaways:

  • High-intensity and aerobic exercises play a vital role in skeletal muscle energy metabolism and oxidative metabolism.
  • Regular exercise can lead to enhanced glucose control and decreased blood sugar levels.
  • Exercise is an effective tool in the management and prevention of diabetes.

As we learn more about skeletal muscle energy metabolism during exercise and oxidative metabolism, we'll see how important exercise, particularly high-intensity and aerobic exercise, is for maintaining metabolic health and managing glucose levels.

Exercise is necessary for maintaining metabolic health. Regular physical activity improves body composition, insulin sensitivity and resting metabolic rate through increases in calories burnt at rest. These changes improve energy use, control glucose and can prevent or manage metabolic disorders like diabetes and metabolic syndrome.

Exercise has many effects on metabolic health. Engaging in physical activity helps our muscles use energy better, particularly high-intensity exercise that breaks down glycogen quickly. Aerobic exercise, on the other hand, helps burn fat.

Regular exercise helps maintain a healthy balance of energy in the body. This reduces the risk of having too much fat. It also reduces the risk of related health problems.

Exercising regularly also improves oxidative metabolism, the process through which our bodies turn fats and carbs into useful energy by using oxygen. This leads to improved endurance, better performance, and, more importantly, efficient glucose control, a crucial element in metabolic health.

Exercise is crucial for maintaining excellent metabolic health and should not be overlooked. It is a powerful, natural instrument for enhancing general health and wellbeing.

Skeletal muscle substrates during exercise

Adenosine triphosphate, or ATP, is the source of energy needed and stored in all cells to allow the body to function optimally. Our muscles have an intricate system for ATP synthesis that uses numerous substrates to produce energy. The substrates used depend on the type of exercise you perform.

High-intensity exercise, such as sprinting or weightlifting, requires rapid energy production, which is mostly supplied by glycogen, a type of stored glucose found in your muscles and liver.

The rapid breakdown of glycogen (glycogenolysis) provides a quick source of glucose for anaerobic metabolism, leading to the formation of lactate. It's crucial to note that while glycogen is a prime energy source for high-intensity exercise, its stores are limited. Therefore, regular consumption of carbohydrates is essential to replenish glycogen stores and sustain high-intensity exercise performance.

During extended, moderate-intensity aerobic exercise, such as jogging or cycling, your muscles predominantly rely on fat oxidation for sustained energy production.

Lipolysis (fat breakdown process) releases fatty acids, which are passed on to muscle cells and used in the mitochondria to make energy. This process, known as beta-oxidation, occurs within the realm of oxidative metabolism, where oxygen is readily available.

While fat is a rich energy source, its breakdown is slower than glycogenolysis. Therefore, the body prefers to utilise fat during lower-intensity, longer-duration activities when the demand for immediate energy is lower.

The type of exercise we engage in influences how our muscles utilise different energy substrates. Glycogen is quickly used for energy quickly during high-intensity activity, while fat oxidation becomes the primary energy source during moderate-intensity aerobic exercise.

Understanding how our bodies use different substrates during exercise provides valuable insight into our metabolic health.

The power of high-intensity exercise in skeletal muscle energy metabolism

High-intensity exercise is a vigorous form of physical activity that pushes your body to its limits. It improves skeletal muscle energy metabolism, a vital process that allows our muscles to efficiently make and use energy.

During high-intensity exercise, our bodies primarily rely on anaerobic glycolysis for energy production. However, this doesn't negate the significance of oxidative metabolism. In fact, evidence indicates that repeated high-intensity exercise sessions can enhance oxidative capacity, essentially training our muscles to better utilise oxygen for energy production, a key factor in endurance and long-term performance.

High-intensity exercise also prompts significant glucose uptake into the skeletal muscles, effectively answering the question, "Will exercise lower blood sugar?" Yes, it certainly can! This mechanism is crucial to maintaining normal blood sugar levels, especially for those with diabetes or pre-diabetes.

Here are some examples of high-intensity exercises that could be incorporated into a routine to support skeletal muscle energy metabolism:

  • High-intensity interval training (HIIT) involves alternating short periods of intense anaerobic exercise with less-intense recovery periods.
  • Sprinting could be done on flat ground or up a hill, either on foot or on a bike.
  • Circuit exercise training consists of a series of exercises performed one after the other with minimal rest in between.
  • Plyometrics are explosive, high-impact exercises such as jump squats or burpees.
  • Heavy weight lifting involves muscle contraction by lifting heavy weights for fewer repetitions, which engages the anaerobic energy system.
  • Intense swimming drills or sprinting laps in a pool doing high-intensity water aerobics can be excellent for boosting skeletal muscle energy metabolism.

Aerobic exercise and oxidative metabolism

While high-intensity exercises are powerful, aerobic exercises should not be overlooked. Engaging in regular, moderate-intensity aerobic exercise like swimming, walking or cycling can significantly stimulate oxidative metabolism.

Aerobic exercise enhances the skeletal muscle's oxidative capacity—the ability to use oxygen to generate energy from carbohydrates and fats. In other words, the more you exercise aerobically, the better your muscles become at using oxygen to convert food into usable energy. This, in turn, leads to improved muscle endurance, metabolic health and efficiency.

Moreover, aerobic exercise increases the capacity of skeletal muscles to absorb glucose from the bloodstream, contributing to the lowering of blood sugar levels. Regular aerobic exercise is therefore a powerful tool in the management and prevention of diabetes.

Here are some examples of aerobic exercises that can be integrated into a routine to support oxidative metabolism:

  • Walking: A brisk walk is a simple, accessible form of aerobic exercise.
  • Running or jogging: This can be done at a steady, moderate pace to maintain a longer duration.
  • Cycling: Whether it's done outdoors or on a stationary bike, cycling is an excellent aerobic activity.
  • Swimming: This is a full-body exercise that can significantly stimulate oxidative metabolism.
  • Dancing: Engaging in dance classes or even freestyle dancing at home can contribute to aerobic fitness.
  • Hiking: This combines the benefits of walking with additional effort due to changes in elevation.
  • Rowing: If you have access to a rowing machine, it provides an effective full-body aerobic workout.
  • Aerobic classes: Fitness classes such as step aerobics, Zumba or spin classes can offer a fun and varied aerobic workout.

The link between exercise and diabetes

Both glycogen and fat metabolism play roles in blood sugar control, which is vital in preventing diabetes. The breakdown of glycogen into glucose directly impacts blood glucose levels, highlighting its importance in glucose management. Similarly, when the body uses fat as a primary fuel source during aerobic exercise, it reduces its reliance on glycogen, thereby helping to maintain blood glucose levels over longer periods.

Extensive research shows the strong correlation between regular exercise and improved glycaemic control, making physical activity a cornerstone in the prevention and management of diabetes. Exercise increases insulin sensitivity, enabling your body to use insulin more efficiently, lowering blood sugar and reducing the risk of developing type 2 diabetes.

One of the key ways exercise supports metabolic health and improves insulin sensitivity is by enhancing the functionality of the mitochondria, often referred to as the powerhouse of the cell. Mitochondria play a vital role in energy production through a process called oxidative phosphorylation.

Oxidative phosphorylation is one of the metabolic pathways that uses energy released by the oxidation of nutrients to produce adenosine triphosphate (ATP). This process occurs within the mitochondrial membrane, and its efficiency is integral to overall metabolic health.

When we engage in exercise, particularly aerobic activity, we're essentially training our mitochondria to be more efficient at oxidative phosphorylation. Regular physical stress from exercise encourages the formation of more mitochondria (a process known as mitochondrial biogenesis) and improves the functionality of existing ones. As a result, your muscles become better at using glucose, which improves insulin sensitivity and helps regulate blood sugar levels.

The effectiveness of exercise in managing diabetes is dependent on regularity, intensity and duration. Both high-intensity and aerobic exercises have unique benefits, and incorporating a mix of both can yield optimal results.

Regular exercise also promotes fat loss and muscle gain, further aiding in blood sugar control and reducing the risk of diabetes-related complications. The role of exercise in managing diabetes is multifaceted and highlights the integral relationship between physical activity and metabolic health.

Understanding the effects of exercise on our metabolic processes and its impact on our health is made easier with tools like Vively, an empowering metabolic health app that helps us make informed decisions and enhance our overall metabolic health through evidence-based strategies.

By tracking your response to different types of exercises and providing personalised guidance based on your data, Vively can help you tailor your workouts to optimise substrate usage and blood glucose control. In this way, Vively is not just a metabolic health app but a partner in your journey towards a healthier, more informed life.

Get irrefutable data about your diet and lifestyle by using your own glucose data with Vively’s CGM Program. We’re currently offering a 20% discount for our annual plan. Sign up here.

Caitlin Simm

Physiotherapist

Caitlin is a physiotherapist with expertise in women’s health, musculoskeletal conditions, exercise-based rehabilitation and pilates

Join Vively's CGM Program

Achieve your health goals using your glucose data

JOIN NOW

Read this next